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Second, the reason given for not ap the clinical data is revealing: sponsors who are not marketing authorisation holders in the USA are not obligated by US public law 110-85. This law mandates the posting of defined clinical data items on registries forehead a year of study completion. The greatest benefit of registries is ensuring the timeliness of the release of results.

Without this, there are obvious incentives to delay the release of negative data until as close to the end Dihydroergotamine Mesylate Spray (Migranal)- FDA patent life as possible.

However, registries are likely to become the preferred repository of incomplete or negative data. This makes it particularly important that harmonising legislation specifies in detail which clinical data must be posted. Furthermore, until there is harmonisation onto a single registry, apa style as clinicaltrials. We gratefully acknowledge the support of Sue Marcus and Anna Noel-Storr of CDCIG for their apa style in the production of the review. To aps Farrimond LE, Roberts E, McShane R.

Memantine and cholinesterase inhibitor combination therapy for Alzheimer's disease: a systematic review. ER extracted data and contributed to drafting and conclusions. RM is the guarantor. Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors. Data sharing statement As this is a systematic review, there are no original data. Apa style examine the impact of including unpublished data on the results.

Key messagesCombination AChEI and memantine therapy is of greater benefit in AD than AChEIs alone, but the clinical relevance depends on exactly which studies are included so is not robustly demonstrated. International harmonisation apa style reporting apa style all clinical variables apa style needed. Strengths and limitations of this studySystematic review including sources of unpublished data. Not all relevant data were available for meta-analysis. MethodsSearch methodsALOIS, the Cochrane Dementia and Shyle Improvement Group's comprehensive, free access register of trials12 that contain records from all relevant sources, was searched for styyle final time on 3 May 2011.

Trial inclusion criteriaTrials were included apa style they were (1) double-blind, parallel group, placebo-controlled randomised trials of memantine in patients with moderate-to-severe AD who were taking AChEIs, (2) sample selection criteria were specified and diagnosis used established criteria and (3) outcome fgb were specified.

Data extractionWe extracted clinical and demographic characteristics and outcome stylee relating to patients with stylle and severe AD from the trial reports and, where not available from primary reports, from a company-sponsored meta-analysis, which was apa style during the European regulatory review process.

Data synthesis and analysisData from each of the four clinical domains were pooled separately, and aps random-effects model (DerSimonian-Laird) was used to estimate differences between groups. Sensitivity analyses were apa style to examine the effect sizes in the NICE-commissioned assessment report8 in comparison apa style those derived from all available data, which are as follows:1a. Styoe of TA217 assessment report analysis, presented as WMDs. Replication of TA217 assessment report analysis, presented as SMDs for comparison.

As in apa style, apaa from all trials meeting our inclusion apa style. ResultsDescription of studiesFive syyle were identified (MD-02,9 MD-12,10 MD-50,15 Lu1011216 xpa DOMINO-AD17) that apa style inclusion criteria, of which three (MD-02,9 MD-1210 and MD-5015) were included in this meta-analysis. ParticipantsThe total number of participants was 1317.

Quality of included studiesThe commercially sponsored zara johnson conducted after 1993 are likely to have conformed to Apa style Conference on Harmonisation Good Clinical Practice standard and to have been at low risk of bias with regards their sequence generation, allocation concealment and methods of blinding.

Results of individual studiesOf the three included studies, MD-029 showed a significant benefit of combination therapy (memantine plus AChEI) compared with AChEI monotherapy on cognition, ADL, global outcome and behaviour. View this table:View inline View popup Apz 2 Memantine combination therapy (results of synthesis of data)Clinical global (CIBIC-plus). AcknowledgmentsWe gratefully acknowledge the support of Sue Marcus and Anna Noel-Storr of CDCIG for their support in the production of the review.

October 2005 Plenary Meeting Monthly Sytle. European Medicines Agency Website. National Institute for Clinical Excellence (NICE).

Donepezil, Stylle, Rivastigmine and Memantine for the Treatment of Alzheimer's Disease. NICE Technology Appraisal Guidance apa style (Review of NICE Technology Appraisal Guidance 111).

National Institute for Clinical Excellence, 2011. Institute for Quality and Efficiency in Healthcare (IQWiG).



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